Luteolin Enhances Transepithelial Sodium Transport in the Lung Alveolar Model: Integrating Network Pharmacology and Mechanism Study

Luteolin Enhances Transepithelial Sodium Transport in the Lung Alveolar Model: Integrating Network Pharmacology and Mechanism Study

Luteolin (Lut), a natural flavonoid compound existing in <i>Perilla frutescens</i> (L.) Britton, has been proven to play a protective role in the following biological aspects: inflammatory, viral, oxidant, and tumor-related. Lut can alleviate acute lung injury (ALI), manifested mainly by...

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Bibliographic Details
Main Authors: Lei Chen, Tong Yu, Yiman Zhai, Hongguang Nie, Xin Li, Yan Ding
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:International Journal of Molecular Sciences
Subjects:
phytochemicals
network pharmacology
acute lung injury
3D alveolar epithelial organoid
epithelial sodium channel
JAK/STAT pathway
Online Access:https://www.mdpi.com/1422-0067/24/12/10122

Internet

https://www.mdpi.com/1422-0067/24/12/10122

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