Vacuolating Cytotoxin A Triggers Mitophagy in Helicobacter pylori-Infected Human Gastric Epithelium Cells

Vacuolating Cytotoxin A Triggers Mitophagy in Helicobacter pylori-Infected Human Gastric Epithelium Cells

Helicobacter pylori (H. pylori)-derived vacuolating cytotoxin A (VacA) causes damage to various organelles, including mitochondria, and induces autophagy and cell death. However, it is unknown whether VacA-induced mitochondrial damage can develop into mitophagy. In this study, we found that H. pylor...

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Bibliographic Details
Main Authors: Li Wang, Juan Yi, Xiao-Yang Yin, Jin-Xia Hou, Jing Chen, Bei Xie, Gang Chen, Qun-Feng Wang, Li-Na Wang, Xiao-Yuan Wang, Jing Sun, Lei-Ming Huo, Tuan-Jie Che, Hu-Lai Wei
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Oncology
Subjects:
Helicobacter pylori
GES-1 cells
autophagy
VacA
mitophagy
TOM complex
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.881829/full

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https://www.frontiersin.org/articles/10.3389/fonc.2022.881829/full

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