Hyperglycemic conditions induce rapid cell dysfunction-promoting transcriptional alterations in human aortic endothelial cells

Abstract Hyperglycemia is a major risk factor in the development of diabetic complications and promotes vascular complications through dysregulation of endothelial cell function. Various mechanisms have been proposed for endothelial cell dysregulation but the early transcriptomic alterations of endo...

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Bibliographic Details
Main Authors: Odmaa Bayaraa, Claire K. Inman, Sneha A. Thomas, Fatima Al Jallaf, Manar Alshaikh, Youssef Idaghdour, Louise Ashall
Format: Article
Language:English
Published: Nature Portfolio 2022-12-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-24999-5