Gene delivery of hypoxia-inducible VEGF targeting collagen effectively improves cardiac function after myocardial infarction

Gene delivery of hypoxia-inducible VEGF targeting collagen effectively improves cardiac function after myocardial infarction

Abstract Vascular endothelial growth factor (VEGF) plays important roles in improvement of cardiac function following myocardial infarction (MI). However, the lack of a steerable delivery system of VEGF targeting the infarcted myocardium reduces the therapeutic efficacy and safety. Here, we construc...

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Main Authors: Jing-Bo Xia, Hai-Yan Wu, Bing-Lin Lai, Li Zheng, Deng-Cheng Zhou, Zao-Shang Chang, Cheng-Zhou Mao, Guang-Hui Liu, Kyu-Sang Park, Hui Zhao, Soo-Ki Kim, Guo-Hua Song, Dong-Qing Cai, Xu-Feng Qi
Format: Article
Language:English
Published: Nature Portfolio 2017-10-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-13547-1

Internet

https://doi.org/10.1038/s41598-017-13547-1

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