Patient-Specific iPSC-Based Models of Huntington’s Disease as a Tool to Study Store-Operated Calcium Entry Drug Targeting

Neurodegenerative pathologies are among the most serious and socially significant problems of modern medicine, along with cardiovascular and oncological diseases. Several attempts have been made to prevent neuronal death using novel drugs targeted to the cell calcium signaling machinery, but the lac...

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Bibliographic Details
Main Authors: Vladimir Vigont, Evgeny Nekrasov, Alexey Shalygin, Konstantin Gusev, Sergey Klushnikov, Sergey Illarioshkin, Maria Lagarkova, Sergey L. Kiselev, Elena Kaznacheyeva
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Pharmacology
Subjects:
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.00696/full