Direct anabolic metabolism of three-carbon propionate to a six-carbon metabolite occurs in vivo across tissues and species

Direct anabolic metabolism of three-carbon propionate to a six-carbon metabolite occurs in vivo across tissues and species

Anabolic metabolism of carbon in mammals is mediated via the one- and two-carbon carriers S-adenosyl methionine and acetyl-coenzyme A. In contrast, anabolic metabolism of three-carbon units via propionate has not been shown to extensively occur. Mammals are primarily thought to oxidize the three-car...

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Bibliographic Details
Main Authors: Mary T. Doan, Michael D. Neinast, Erika L. Varner, Kenneth C. Bedi, Jr., David Bartee, Helen Jiang, Sophie Trefely, Peining Xu, Jay P. Singh, Cholsoon Jang, J. Eduardo Rame, Donita C. Brady, Jordan L. Meier, Kenneth B. Marguiles, Zoltan Arany, Nathaniel W. Snyder
Format: Article
Language:English
Published: Elsevier 2022-06-01
Series:Journal of Lipid Research
Subjects:
Metabolism
propionate
anabolism
acetyl-CoA
condensation reaction
2M2PE-CoA
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227522000578

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http://www.sciencedirect.com/science/article/pii/S0022227522000578

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