Potency-Enhancing Mutations of Gating Modifier Toxins for the Voltage-Gated Sodium Channel Na<sub>V</sub>1.7 Can Be Predicted Using Accurate Free-Energy Calculations

Potency-Enhancing Mutations of Gating Modifier Toxins for the Voltage-Gated Sodium Channel Na<sub>V</sub>1.7 Can Be Predicted Using Accurate Free-Energy Calculations

Gating modifier toxins (GMTs) isolated from venomous organisms such as Protoxin-II (ProTx-II) and Huwentoxin-IV (HwTx-IV) that inhibit the voltage-gated sodium channel Na<sub>V</sub>1.7 by binding to its voltage-sensing domain II (VSDII) have been extensively investigated as non-opioid a...

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Bibliographic Details
Main Authors: Dana Katz, Dan Sindhikara, Michael DiMattia, Abba E. Leffler
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Toxins
Subjects:
gating-modifier toxin
free-energy perturbation
sodium channel
drug discovery
Online Access:https://www.mdpi.com/2072-6651/13/3/193

Internet

https://www.mdpi.com/2072-6651/13/3/193

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