Connexin Mutants Compromise the Lens Circulation and Cause Cataracts through Biomineralization

Connexin Mutants Compromise the Lens Circulation and Cause Cataracts through Biomineralization

Gap junction-mediated intercellular communication facilitates the circulation of ions, small molecules, and metabolites in the avascular eye lens. Mutants of the lens fiber cell gap junction proteins, connexin46 (Cx46) and connexin50 (Cx50), cause cataracts in people and in mice. Studies in mouse mo...

Full description

Bibliographic Details
Main Authors: Viviana M. Berthoud, Junyuan Gao, Peter J. Minogue, Oscar Jara, Richard T. Mathias, Eric C. Beyer
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:International Journal of Molecular Sciences
Subjects:
cataract
intercellular communication
connexin mutant
calcium
calcification
biomineralization
Online Access:https://www.mdpi.com/1422-0067/21/16/5822

Internet

https://www.mdpi.com/1422-0067/21/16/5822

Similar Items