Drug specificity and affinity are encoded in the probability of cryptic pocket opening in myosin motor domains

Drug specificity and affinity are encoded in the probability of cryptic pocket opening in myosin motor domains

The design of compounds that can discriminate between closely related target proteins remains a central challenge in drug discovery. Specific therapeutics targeting the highly conserved myosin motor family are urgently needed as mutations in at least six of its members cause numerous diseases. Allos...

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Bibliographic Details
Main Authors: Artur Meller, Jeffrey M Lotthammer, Louis G Smith, Borna Novak, Lindsey A Lee, Catherine C Kuhn, Lina Greenberg, Leslie A Leinwand, Michael J Greenberg, Gregory R Bowman
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-01-01
Series:eLife
Subjects:
myosin
specificity
molecular dynamics
cryptic pockets
protein dynamics
Online Access:https://elifesciences.org/articles/83602

Internet

https://elifesciences.org/articles/83602

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