The RGD region of bone sialoprotein affects metabolic activity in mice

The RGD region of bone sialoprotein affects metabolic activity in mice

IntroductionBone sialoprotein (BSP) is a key regulator of mineralized tissue formation. Previously, we generated BSP-KAE knock-in mice (KAEKI mice) by substituting a non-function KAE (lysine-alanine-glutamic acid) for the integrin-binding RGD (arginine-glycine-aspartic acid) sequence and reported a...

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Bibliographic Details
Main Authors: Karin Nagasaki, Atsuhiro Nagasaki, Jocelyn M. Taylor, Bernice D. Kear, Yinyan Ma, Martha J. Somerman, Oksana Gavrilova
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Dental Medicine
Subjects:
mineralized tissues
arginine-glycine-aspartic acid (RGD)
bone sialoprotein
metabolic activity
obesity
endocrinology
Online Access:https://www.frontiersin.org/articles/10.3389/fdmed.2023.1124084/full

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https://www.frontiersin.org/articles/10.3389/fdmed.2023.1124084/full

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