Protein production dynamics and physiological adaptation of recombinant Komagataella phaffii at near-zero growth rates

Protein production dynamics and physiological adaptation of recombinant Komagataella phaffii at near-zero growth rates

Abstract Background Specific productivity (qP) in yeast correlates with growth, typically peaking at intermediate or maximum specific growth rates (μ). Understanding the factors limiting productivity at extremely low μ might reveal decoupling strategies, but knowledge of production dynamics and phys...

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Main Authors: Corinna Rebnegger, Benjamin L. Coltman, Viktoria Kowarz, David A. Peña, Axel Mentler, Christina Troyer, Stephan Hann, Harald Schöny, Gunda Koellensperger, Diethard Mattanovich, Brigitte Gasser
Format: Article
Language:English
Published: BMC 2024-02-01
Series:Microbial Cell Factories
Online Access:https://doi.org/10.1186/s12934-024-02314-3

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https://doi.org/10.1186/s12934-024-02314-3

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