Overexpression of a Short Sulfonylurea Splice Variant Increases Cardiac Glucose Uptake and Uncouples Mitochondria by Regulating ROMK Activity

Overexpression of a Short Sulfonylurea Splice Variant Increases Cardiac Glucose Uptake and Uncouples Mitochondria by Regulating ROMK Activity

The mitochondrial splice variant of the sulfonylurea receptor (SUR2A-55) is associated with protection from myocardial ischemia-reperfusion (IR) injury, increased mitochondrial ATP sensitive K<sup>+</sup> channel activity (mitoK<sub>ATP</sub>) and altered glucose metabolism....

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Bibliographic Details
Main Authors: Sarah K. El-Meanawy, Holly Dooge, Allison C. Wexler, Anna C. Kosmach, Lara Serban, Elizabeth A. Santos, Francisco J. Alvarado, Timothy A. Hacker, Mohun Ramratnam
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Life
Subjects:
K<sub>ATP</sub> channel
sulfonylurea receptor
renal outer medullary potassium channel
myocardial ischemic reperfusion injury
mitoK<sub>ATP</sub>
Online Access:https://www.mdpi.com/2075-1729/13/4/1015

Internet

https://www.mdpi.com/2075-1729/13/4/1015

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