Design and biological evaluation of 3-substituted quinazoline-2,4(1H,3H)-dione derivatives as dual c-Met/VEGFR-2-TK inhibitors

Design and biological evaluation of 3-substituted quinazoline-2,4(1H,3H)-dione derivatives as dual c-Met/VEGFR-2-TK inhibitors

AbstractThe dual c-Met/vascular endothelial growth factor receptor 2 (VEGFR-2) TK inhibition is a good strategy to overcome therapeutic resistance to small molecules VEGFR-2 inhibitors. In this study, we designed 3-substituted quinazoline-2,4(1H,3H)-dione derivatives as dual c-Met/VEGFR-2 TK inhibit...

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Bibliographic Details
Main Authors: Abdelfattah Hassan, Fawzy A. F. Mubarak, Ihsan A. Shehadi, Ahmed M. Mosallam, Hussain Temairk, Mohamed Badr, Aboubakr H. Abdelmonsef
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
c-Met
VEGFR-2
colorectal cancer
quinazoline-24(1H3H)-dione
N-acylhydrazone
Online Access:https://www.tandfonline.com/doi/10.1080/14756366.2023.2189578

Internet

https://www.tandfonline.com/doi/10.1080/14756366.2023.2189578

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