Design and biological evaluation of 3-substituted quinazoline-2,4(1H,3H)-dione derivatives as dual c-Met/VEGFR-2-TK inhibitors

Design and biological evaluation of 3-substituted quinazoline-2,4(1H,3H)-dione derivatives as dual c-Met/VEGFR-2-TK inhibitors

The dual c-Met/vascular endothelial growth factor receptor 2 (VEGFR-2) TK inhibition is a good strategy to overcome therapeutic resistance to small molecules VEGFR-2 inhibitors. In this study, we designed 3-substituted quinazoline-2,4(1H,3H)-dione derivatives as dual c-Met/VEGFR-2 TK inhibitors. We...

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Bibliographic Details
Main Authors:	Abdelfattah Hassan, Fawzy A. F. Mubarak, Ihsan A. Shehadi, Ahmed M. Mosallam, Hussain Temairk, Mohamed Badr, Aboubakr H. Abdelmonsef
Format:	Article
Language:	English
Published:	Taylor & Francis Group 2023-12-01
Series:	Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:	c-Met VEGFR-2 colorectal cancer quinazoline-24(1H3H)-dione N-acylhydrazone
Online Access:	https://www.tandfonline.com/doi/10.1080/14756366.2023.2189578

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