Targeting the Structural Maturation Pathway of HIV-1 Reverse Transcriptase

Targeting the Structural Maturation Pathway of HIV-1 Reverse Transcriptase

Formation of active HIV-1 reverse transcriptase (RT) proceeds via a structural maturation process that involves subdomain rearrangements and formation of an asymmetric p66/p66′ homodimer. These studies were undertaken to evaluate whether the information about this maturation process can be used to i...

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Bibliographic Details
Main Authors: Thomas W. Kirby, Scott A. Gabel, Eugene F. DeRose, Lalith Perera, Juno M. Krahn, Lars C. Pedersen, Robert E. London
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:Biomolecules
Subjects:
HIV-1 reverse transcriptase
RT structural maturation
maturation inhibitors
RT polymerase domain
ground state stabilization
RT dimerization inhibitor
Online Access:https://www.mdpi.com/2218-273X/13/11/1603

Internet

https://www.mdpi.com/2218-273X/13/11/1603

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