PDZD8-mediated endoplasmic reticulum–mitochondria associations regulate sympathetic drive and blood pressure through the intervention of neuronal mitochondrial homeostasis in stress-induced hypertension

PDZD8-mediated endoplasmic reticulum–mitochondria associations regulate sympathetic drive and blood pressure through the intervention of neuronal mitochondrial homeostasis in stress-induced hypertension

Neuronal hyperexcitation in the rostral ventrolateral medulla (RVLM) drives heightened sympathetic nerve activity and contributes to the etiology of stress-induced hypertension (SIH). Maintenance of mitochondrial functions is central to neuronal homeostasis. PDZD8, an endoplasmic reticulum (ER) tran...

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Bibliographic Details
Main Authors: Tianfeng Liu, Linping Wang, Gaojun Chen, Lei Tong, Xuanxuan Ye, Hui Yang, Haisheng Liu, Haili Zhang, Wen Lu, Shuai Zhang, Dongshu Du
Format: Article
Language:English
Published: Elsevier 2023-07-01
Series:Neurobiology of Disease
Subjects:
Endoplasmic reticulum–mitochondria associations
Mitochondrial dysfunction
PDZD8
Rostral ventrolateral medulla
Stress-induced hypertension
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996123001882

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http://www.sciencedirect.com/science/article/pii/S0969996123001882

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