KRAS mutation: from undruggable to druggable in cancer

Abstract Cancer is the leading cause of death worldwide, and its treatment and outcomes have been dramatically revolutionised by targeted therapies. As the most frequently mutated oncogene, Kirsten rat sarcoma viral oncogene homologue (KRAS) has attracted substantial attention. The understanding of...

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Bibliographic Details
Main Authors: Lamei Huang, Zhixing Guo, Fang Wang, Liwu Fu
Format: Article
Language:English
Published: Nature Publishing Group 2021-11-01
Series:Signal Transduction and Targeted Therapy
Online Access:https://doi.org/10.1038/s41392-021-00780-4