DNA Methyltransferase Inhibitor Promotes Human CD4+CD25hFOXP3+ Regulatory T Lymphocyte Induction under Suboptimal TCR Stimulation

DNA Methyltransferase Inhibitor Promotes Human CD4+CD25hFOXP3+ Regulatory T Lymphocyte Induction under Suboptimal TCR Stimulation

The master transcription factor FOXP3 regulates the differentiation, homeostasis, and suppressor function of CD4+ regulatory T (Treg) cells, which are critical in maintaining immune tolerance. Epigenetic regulation of FOXP3 expression has been demonstrated to be important to Treg cell development, b...

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Bibliographic Details
Main Authors: Chun-Hao Lu, Cheng-Jang Wu, Cheng-Chi Chan, Duc T. Nguyen, Kuo-Ray Lin, Syh-Jae Lin, Li-Chen Chen, Jeffrey Jong-Yong Yen, Ming-Ling Kuo
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-11-01
Series:Frontiers in Immunology
Subjects:
Foxp3
Epigenetic regulation
immunological tolerance
Human regulatory T cell
suboptimal TCR stimulation
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00488/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2016.00488/full

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