Isoform- and Paralog-Switching in IR-Signaling: When Diabetes Opens the Gates to Cancer

Isoform- and Paralog-Switching in IR-Signaling: When Diabetes Opens the Gates to Cancer

Insulin receptor (IR) and IR-related signaling defects have been shown to trigger insulin-resistance in insulin-dependent cells and ultimately to give rise to type 2 diabetes in mammalian organisms. IR expression is ubiquitous in mammalian tissues, and its over-expression is also a common finding in...

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Bibliographic Details
Main Authors: Pierluigi Scalia, Antonio Giordano, Caroline Martini, Stephen J. Williams
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Biomolecules
Subjects:
<i>IR</i>: insulin receptor
<i>IGF</i>: insulin-like growth factor
<i>HIF:</i> hypoxia-inducible factor
<i>Isoform:</i> for the scope of this review, the term isoform is restricted to products of alternatively spliced coding genes
<i>Paralog</i>: the product of gene variants with high sequence similarity encoded by duplicated genes in the genome
MAPK-ERK: Mitogen-activated protein Kinase-Extracellular-signal-regulated Kinase
Online Access:https://www.mdpi.com/2218-273X/10/12/1617

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https://www.mdpi.com/2218-273X/10/12/1617

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