Safety of allogeneic hematopoietic cell transplant in adults after CD19-targeted CAR T-cell therapy

Safety of allogeneic hematopoietic cell transplant in adults after CD19-targeted CAR T-cell therapy

Abstract: Allogeneic hematopoietic cell transplantation (allo-HCT) is offered to selected patients after chimeric antigen receptor–modified T-cell (CAR-T) therapy. Lymphodepleting chemotherapy and CAR-T therapy have immunosuppressive and immunomodulatory effects that could alter the safety profile o...

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Bibliographic Details
Main Authors: Mazyar Shadman, Jordan Gauthier, Kevin A. Hay, Jenna M. Voutsinas, Filippo Milano, Ang Li, Alexandre V. Hirayama, Mohamed L. Sorror, Sindhu Cherian, Xueyan Chen, Ryan D. Cassaday, Brian G. Till, Ajay K. Gopal, Brenda M. Sandmaier, David G. Maloney, Cameron J. Turtle
Format: Article
Language:English
Published: Elsevier 2019-10-01
Series:Blood Advances
Online Access:http://www.sciencedirect.com/science/article/pii/S2473952920318267

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http://www.sciencedirect.com/science/article/pii/S2473952920318267

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