ACTN1 promotes HNSCC tumorigenesis and cisplatin resistance by enhancing MYH9-dependent degradation of GSK-3β and integrin β1-mediated phosphorylation of FAK

Abstract Background Head and neck squamous cell carcinoma (HNSCC) is one of the most common malignant tumors globally. Understanding the molecular basis of tumor progression and drug resistance can offer innovative strategies to enhance clinical outcomes for HNSCC patients. Methods The cytoskeletal...

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Bibliographic Details
Main Authors: Li Cui, Ye Lu, Jiarong Zheng, Bing Guo, Xinyuan Zhao
Format: Article
Language:English
Published: BMC 2023-12-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Online Access:https://doi.org/10.1186/s13046-023-02904-w