The structure of EXTL3 helps to explain the different roles of bi-domain exostosins in heparan sulfate synthesis

The structure of EXTL3 helps to explain the different roles of bi-domain exostosins in heparan sulfate synthesis

Heparan sulphate (HS)—a common cell surface decoration—is a carbohydrate of alternating sugars assembled by bi-domain enzymes such as EXTL3. Here, authors present the structure of EXTL3, explain EXTL3 lost activity, and propose that HS extension is distributive.

Bibliographic Details
Main Authors: L. F. L. Wilson, T. Dendooven, S. W. Hardwick, A. Echevarría-Poza, T. Tryfona, K. B. R. M. Krogh, D. Y. Chirgadze, B. F. Luisi, D. T. Logan, K. Mani, P. Dupree
Format: Article
Language:English
Published: Nature Portfolio 2022-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-31048-2

Internet

https://doi.org/10.1038/s41467-022-31048-2

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