The structure of EXTL3 helps to explain the different roles of bi-domain exostosins in heparan sulfate synthesis
Heparan sulphate (HS)—a common cell surface decoration—is a carbohydrate of alternating sugars assembled by bi-domain enzymes such as EXTL3. Here, authors present the structure of EXTL3, explain EXTL3 lost activity, and propose that HS extension is distributive.
Bibliographic Details
| Main Authors: |
L. F. L. Wilson,
T. Dendooven,
S. W. Hardwick,
A. Echevarría-Poza,
T. Tryfona,
K. B. R. M. Krogh,
D. Y. Chirgadze,
B. F. Luisi,
D. T. Logan,
K. Mani,
P. Dupree |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2022-06-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-022-31048-2
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