PD-1 and PD-L1 in cancer immunotherapy: clinical implications and future considerations

PD-1 and PD-L1 in cancer immunotherapy: clinical implications and future considerations

Programmed death-1 (PD-1) is a cell surface receptor that functions as a T cell checkpoint and plays a central role in regulating T cell exhaustion. Binding of PD-1 to its ligand, programmed death-ligand 1 (PD-L1), activates downstream signaling pathways and inhibits T cell activation. Moreover abno...

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Bibliographic Details
Main Authors: Yongshuai Jiang, Ming Chen, Hong Nie, Yuanyang Yuan
Format: Article
Language:English
Published: Taylor & Francis Group 2019-05-01
Series:Human Vaccines & Immunotherapeutics
Subjects:
pd-1
pd-l1
checkpoint
tumor
immunotherapy
Online Access:http://dx.doi.org/10.1080/21645515.2019.1571892

Internet

http://dx.doi.org/10.1080/21645515.2019.1571892

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