Subunit compensation and plasticity of synaptic GABAA receptors induced by ethanol in α4 subunit knockout mice

Subunit compensation and plasticity of synaptic GABAA receptors induced by ethanol in α4 subunit knockout mice

There is considerable evidence that ethanol (EtOH) potentiates γ-aminobutyric acid type A receptor (GABAAR) action, but only GABAARs containing δ subunits appear sensitive to low mM EtOH. The α4 and δ subunits co-assemble into GABAARs which are relatively highly expressed at extrasynaptic locations...

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Bibliographic Details
Main Authors: Asha eSuryanarayanan, Jing eLiang, Edward M Meyer, A. Kerstin eLindemeyer, Dev eChandra, Gregg E Homanics, Werner eSieghart, Richard W Olsen, Igor eSpigelman
Format: Article
Language:English
Published: Frontiers Media S.A. 2011-09-01
Series:Frontiers in Neuroscience
Subjects:
Dentate Gyrus
Synaptic Transmission
dependence
tolerance
alcohol
withdrawal
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnins.2011.00110/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnins.2011.00110/full

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