Targeted mutations in IFNα2 improve its antiviral activity against various viruses

Targeted mutations in IFNα2 improve its antiviral activity against various viruses

ABSTRACTDuring viral infections, type I interferons (IFN) are induced and play a key role in counteracting initial viral spread. Twelve different human IFNα subtypes exist that bind the same receptor; however, they elicit unique host responses and display distinct potencies of antiviral activities....

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Bibliographic Details
Main Authors: Zehra Karakoese, Vu-Thuy Khanh Le-Trilling, Jonas Schuhenn, Sandra Francois, Mengji Lu, Jia Liu, Mirko Trilling, Daniel Hoffmann, Ulf Dittmer, Kathrin Sutter
Format: Article
Language:English
Published: American Society for Microbiology 2023-12-01
Series:mBio
Subjects:
interferons
hepatitis B virus
antiviral therapy
IFNAR
human immunodeficiency virus
Online Access:https://journals.asm.org/doi/10.1128/mbio.02357-23

Internet

https://journals.asm.org/doi/10.1128/mbio.02357-23

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