Memory CD4 + T-Cells Expressing HLA-DR Contribute to HIV Persistence During Prolonged Antiretroviral Therapy

Memory CD4 + T-Cells Expressing HLA-DR Contribute to HIV Persistence During Prolonged Antiretroviral Therapy

To date, most assays for measuring the human immunodeficiency virus (HIV-1) reservoir do not include memory CD4+ T-cells expressing the activation marker, human leukocyte antigen-antigen D related (HLA-DR). However, little is known concerning the role these cells play in maintaining persistent HIV-1...

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Bibliographic Details
Main Authors: Eunok Lee, Peter Bacchetti, Jeffery Milush, Wei Shao, Eli Boritz, Daniel Douek, Remi Fromentin, Teri Liegler, Rebecca Hoh, Steve G. Deeks, Frederick M. Hecht, Nicolas Chomont, Sarah Palmer
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-09-01
Series:Frontiers in Microbiology
Subjects:
HLA-DR
CD4+ T-cells
prolonged ART
HIV persistence
cell activation/exhaustion markers
cellular proliferation
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2019.02214/full

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https://www.frontiersin.org/article/10.3389/fmicb.2019.02214/full

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