Memory CD4 + T-Cells Expressing HLA-DR Contribute to HIV Persistence During Prolonged Antiretroviral Therapy

Memory CD4 + T-Cells Expressing HLA-DR Contribute to HIV Persistence During Prolonged Antiretroviral Therapy

To date, most assays for measuring the human immunodeficiency virus (HIV-1) reservoir do not include memory CD4+ T-cells expressing the activation marker, human leukocyte antigen-antigen D related (HLA-DR). However, little is known concerning the role these cells play in maintaining persistent HIV-1...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron: Eunok Lee, Peter Bacchetti, Jeffery Milush, Wei Shao, Eli Boritz, Daniel Douek, Remi Fromentin, Teri Liegler, Rebecca Hoh, Steve G. Deeks, Frederick M. Hecht, Nicolas Chomont, Sarah Palmer
Fformat: Erthygl
Iaith:English
Cyhoeddwyd: Frontiers Media S.A. 2019-09-01
Cyfres:Frontiers in Microbiology
Pynciau:
HLA-DR
CD4+ T-cells
prolonged ART
HIV persistence
cell activation/exhaustion markers
cellular proliferation
Mynediad Ar-lein:https://www.frontiersin.org/article/10.3389/fmicb.2019.02214/full

Rhyngrwyd

https://www.frontiersin.org/article/10.3389/fmicb.2019.02214/full

Eitemau Tebyg