GrpEL1 overexpression mitigates hippocampal neuron damage via mitochondrial unfolded protein response after experimental status epilepticus

GrpEL1 overexpression mitigates hippocampal neuron damage via mitochondrial unfolded protein response after experimental status epilepticus

Background: Despite the availability of various antiepileptic treatments, approximately 30 % of epilepsy patients remain refractory to conventional therapies, underscoring the need for neuroprotective strategies. This study investigates the role of GrpEL1 in modulating the mitochondrial unfolded pro...

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Bibliographic Details
Main Authors: Minjia Xie, Xin Wu, Xi Liu, Longyuan Li, Feng Gu, Xinyu Tao, Bingyi Song, Lei Bai, Di Li, Haitao Shen, Zongqi Wang, Wei Gao
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:Neurobiology of Disease
Subjects:
GrpEL1
Mitochondrial unfolded protein response (UPRmt)
Status epilepticus
Hippocampal neurons
Neuronal protection
Mitochondrial dysfunction
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996125000543

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http://www.sciencedirect.com/science/article/pii/S0969996125000543

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