Modulation of the activity of Sp transcription factors by mithramycin analogues as a new strategy for treatment of metastatic prostate cancer.

Modulation of the activity of Sp transcription factors by mithramycin analogues as a new strategy for treatment of metastatic prostate cancer.

Deregulated activity of transcription factors (TFs) of the Sp/KLF family, like Sp1, Sp3 and Sp4, and consequent over-expression of Sp-regulated genes occur frequently in human cancers. This provides the rationale for development of inhibitors of Sp TFs as cancer therapeutics. Mithramycin A (MTM-A) i...

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Bibliographic Details
Main Authors: Anastasia Malek, Luz-Elena Núñez, Marco Magistri, Lara Brambilla, Sandra Jovic, Giuseppina M Carbone, Francisco Morís, Carlo V Catapano
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3334962?pdf=render

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http://europepmc.org/articles/PMC3334962?pdf=render

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