Characterizing the allele-specific gene expression landscape in high hyperdiploid acute lymphoblastic leukemia with BASE

Characterizing the allele-specific gene expression landscape in high hyperdiploid acute lymphoblastic leukemia with BASE

Abstract Somatic copy number variations (CNVs), including abnormal chromosome numbers and structural changes leading to gain or loss of genetic material, play a crucial role in initiation and progression of cancer. CNVs are believed to cause gene dosage imbalances and modify cis-regulatory elements,...

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Bibliographic Details
Main Authors: Jonas Andersson, Efe Aydın, Rebeqa Gunnarsson, Henrik Lilljebjörn, Thoas Fioretos, Bertil Johansson, Kajsa Paulsson, Minjun Yang
Format: Article
Language:English
Published: Nature Portfolio 2024-10-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-024-73743-8

Internet

https://doi.org/10.1038/s41598-024-73743-8

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