A metabolic dysfunction-associated steatotic liver acinus biomimetic induces pancreatic islet dysfunction in a coupled microphysiology system

A metabolic dysfunction-associated steatotic liver acinus biomimetic induces pancreatic islet dysfunction in a coupled microphysiology system

Abstract Preclinical and clinical studies suggest that lipid-induced hepatic insulin resistance is a primary defect that predisposes to dysfunction in islets, implicating a perturbed liver-pancreas axis underlying the comorbidity of T2DM and MASLD. To investigate this hypothesis, we developed a huma...

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Bibliographic Details
Main Authors: Julio Aleman, Ravikumar K, Connor Wiegand, Mark E. Schurdak, Lawrence Vernetti, Dillon Gavlock, Celeste Reese, Richard DeBiasio, Greg LaRocca, Yulder Daniel Angarita, Albert Gough, Alejandro Soto-Gutierrez, Jaideep Behari, Vijay K. Yechoor, Mark T. Miedel, Andrew M. Stern, Ipsita Banerjee, D. Lansing Taylor
Format: Article
Language:English
Published: Nature Portfolio 2024-10-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-024-07006-7

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https://doi.org/10.1038/s42003-024-07006-7

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