Subarachnoid hemorrhage-associated brain injury and neurobehavioral deficits are reversed with synthetic adropin treatment through sustained Ser1179 phosphorylation of endothelial nitric oxide synthase

Subarachnoid hemorrhage-associated brain injury and neurobehavioral deficits are reversed with synthetic adropin treatment through sustained Ser1179 phosphorylation of endothelial nitric oxide synthase

BackgroundSubarachnoid hemorrhage (SAH) is a life-threatening vascular condition without satisfactory treatment options. The secreted peptide adropin is highly expressed in the human brain and has neuroprotective effects in brain injury models, including actions involving the cerebrovasculature. Her...

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Detalhes bibliográficos
Principais autores: William S. Dodd, Devan Patel, Dimitri Laurent, Brandon Lucke-Wold, Koji Hosaka, Richard D. Johnson, Nohra Chalouhi, Andrew A. Butler, Eduardo Candelario-Jalil, Brian L. Hoh
Formato: Artigo
Idioma:English
Publicado em: Frontiers Media S.A. 2024-03-01
coleção:Frontiers in Stroke
Assuntos:
subarachnoid hemorrhage
adropin
eNOS
vasospasm
delayed cerebral ischemia
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fstro.2024.1371140/full

Internet

https://www.frontiersin.org/articles/10.3389/fstro.2024.1371140/full

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