Mucosal vaccination induces protection against SARS-CoV-2 in the absence of detectable neutralizing antibodies

Mucosal vaccination induces protection against SARS-CoV-2 in the absence of detectable neutralizing antibodies

Abstract A candidate multigenic SARS-CoV-2 vaccine based on an MVA vector expressing both viral N and S proteins (MVA-S + N) was immunogenic, and induced T-cell responses and binding antibodies to both antigens but in the absence of detectable neutralizing antibodies. Intranasal immunization with th...

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Bibliographic Details
Main Authors: Chaojie Zhong, Hongjie Xia, Awadalkareem Adam, Binbin Wang, Renee L. Hajnik, Yuejin Liang, Grace H. Rafael, Jing Zou, Xiaofang Wang, Jiaren Sun, Lynn Soong, Alan D. T. Barrett, Scott C. Weaver, Pei-Yong Shi, Tian Wang, Haitao Hu
Format: Article
Language:English
Published: Nature Portfolio 2021-11-01
Series:npj Vaccines
Online Access:https://doi.org/10.1038/s41541-021-00405-5

Internet

https://doi.org/10.1038/s41541-021-00405-5

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