The effects of the NMDAR co-agonist d-serine on the structure and function of optic tectal neurons in the developing visual system
Abstract The N-methyl-d-aspartate type glutamate receptor (NMDAR) is a molecular coincidence detector which converts correlated patterns of neuronal activity into cues for the structural and functional refinement of developing circuits in the brain. d-serine is an endogenous co-agonist of the NMDAR....
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-08-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-39951-4 |
| _version_ | 1797560029078880256 |
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| author | Zahraa Chorghay Vanessa J. Li Anne Schohl Arna Ghosh Edward S. Ruthazer |
| author_facet | Zahraa Chorghay Vanessa J. Li Anne Schohl Arna Ghosh Edward S. Ruthazer |
| author_sort | Zahraa Chorghay |
| collection | DOAJ |
| description | Abstract The N-methyl-d-aspartate type glutamate receptor (NMDAR) is a molecular coincidence detector which converts correlated patterns of neuronal activity into cues for the structural and functional refinement of developing circuits in the brain. d-serine is an endogenous co-agonist of the NMDAR. We investigated the effects of potent enhancement of NMDAR-mediated currents by chronic administration of saturating levels of d-serine on the developing Xenopus retinotectal circuit. Chronic exposure to the NMDAR co-agonist d-serine resulted in structural and functional changes in the optic tectum. In immature tectal neurons, d-serine administration led to more compact and less dynamic tectal dendritic arbors, and increased synapse density. Calcium imaging to examine retinotopy of tectal neurons revealed that animals raised in d-serine had more compact visual receptive fields. These findings provide insight into how the availability of endogenous NMDAR co-agonists like d-serine at glutamatergic synapses can regulate the refinement of circuits in the developing brain. |
| first_indexed | 2024-03-10T17:53:39Z |
| format | Article |
| id | doaj.art-379033e731bd4b3c9cacd71cbb63ef2b |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-10T17:53:39Z |
| publishDate | 2023-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-379033e731bd4b3c9cacd71cbb63ef2b2023-11-20T09:15:32ZengNature PortfolioScientific Reports2045-23222023-08-0113111310.1038/s41598-023-39951-4The effects of the NMDAR co-agonist d-serine on the structure and function of optic tectal neurons in the developing visual systemZahraa Chorghay0Vanessa J. Li1Anne Schohl2Arna Ghosh3Edward S. Ruthazer4Montreal Neurological Institute-Hospital and Department of Neurology and Neurosurgery, McGill UniversityMontreal Neurological Institute-Hospital and Department of Neurology and Neurosurgery, McGill UniversityMontreal Neurological Institute-Hospital and Department of Neurology and Neurosurgery, McGill UniversityMILAMontreal Neurological Institute-Hospital and Department of Neurology and Neurosurgery, McGill UniversityAbstract The N-methyl-d-aspartate type glutamate receptor (NMDAR) is a molecular coincidence detector which converts correlated patterns of neuronal activity into cues for the structural and functional refinement of developing circuits in the brain. d-serine is an endogenous co-agonist of the NMDAR. We investigated the effects of potent enhancement of NMDAR-mediated currents by chronic administration of saturating levels of d-serine on the developing Xenopus retinotectal circuit. Chronic exposure to the NMDAR co-agonist d-serine resulted in structural and functional changes in the optic tectum. In immature tectal neurons, d-serine administration led to more compact and less dynamic tectal dendritic arbors, and increased synapse density. Calcium imaging to examine retinotopy of tectal neurons revealed that animals raised in d-serine had more compact visual receptive fields. These findings provide insight into how the availability of endogenous NMDAR co-agonists like d-serine at glutamatergic synapses can regulate the refinement of circuits in the developing brain.https://doi.org/10.1038/s41598-023-39951-4 |
| spellingShingle | Zahraa Chorghay Vanessa J. Li Anne Schohl Arna Ghosh Edward S. Ruthazer The effects of the NMDAR co-agonist d-serine on the structure and function of optic tectal neurons in the developing visual system Scientific Reports |
| title | The effects of the NMDAR co-agonist d-serine on the structure and function of optic tectal neurons in the developing visual system |
| title_full | The effects of the NMDAR co-agonist d-serine on the structure and function of optic tectal neurons in the developing visual system |
| title_fullStr | The effects of the NMDAR co-agonist d-serine on the structure and function of optic tectal neurons in the developing visual system |
| title_full_unstemmed | The effects of the NMDAR co-agonist d-serine on the structure and function of optic tectal neurons in the developing visual system |
| title_short | The effects of the NMDAR co-agonist d-serine on the structure and function of optic tectal neurons in the developing visual system |
| title_sort | effects of the nmdar co agonist d serine on the structure and function of optic tectal neurons in the developing visual system |
| url | https://doi.org/10.1038/s41598-023-39951-4 |
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