Temporal Control of the <named-content content-type="genus-species">Helicobacter pylori</named-content> Cag Type IV Secretion System in a Mongolian Gerbil Model of Gastric Carcinogenesis

Temporal Control of the <named-content content-type="genus-species">Helicobacter pylori</named-content> Cag Type IV Secretion System in a Mongolian Gerbil Model of Gastric Carcinogenesis

ABSTRACT The Helicobacter pylori Cag type IV secretion system (T4SS) translocates the effector protein CagA and nonprotein bacterial constituents into host cells. In this study, we infected Mongolian gerbils with an H. pylori strain in which expression of the cagUT operon (required for Cag T4SS acti...

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Bibliographic Details
Main Authors: Aung Soe Lin, Mark S. McClain, Amber C. Beckett, Rhonda R. Caston, M. Lorena Harvey, Beverly R. E. A. Dixon, Anne M. Campbell, Jennifer H. B. Shuman, Neha Sawhney, Alberto G. Delgado, John T. Loh, M. Blanca Piazuelo, Holly M. Scott Algood, Timothy L. Cover
Format: Article
Language:English
Published: American Society for Microbiology 2020-06-01
Series:mBio
Subjects:
Helicobacter pylori
type IV secretion system
gastric cancer
carcinogenesis
animal model
hit-and-run hypothesis
Online Access:https://journals.asm.org/doi/10.1128/mBio.01296-20

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https://journals.asm.org/doi/10.1128/mBio.01296-20

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