O-GlcNAc transferase couples MRE11 to transcriptionally active chromatin to suppress DNA damage

O-GlcNAc transferase couples MRE11 to transcriptionally active chromatin to suppress DNA damage

Abstract Background Transcription, metabolism and DNA damage response are tightly regulated to preserve the genomic integrity, and O-GlcNAc transferase (OGT) is positioned to connect the three. Prostate cancer is the most common cancer in men, and androgen-ablation therapy halts disease progression....

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Bibliographic Details
Main Authors: Aishwarya Gondane, Samuel Girmay, Alma Helevä, Satu Pallasaho, Massimo Loda, Harri M. Itkonen
Format: Article
Language:English
Published: BMC 2022-02-01
Series:Journal of Biomedical Science
Subjects:
DNA damage
Cyclin-dependent kinase 9
O-GlcNAc transferase
MRE11
Castration-resistant prostate cancer
Online Access:https://doi.org/10.1186/s12929-022-00795-1

Internet

https://doi.org/10.1186/s12929-022-00795-1

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