Antibiotic that inhibits trans-translation blocks binding of EF-Tu to tmRNA but not to tRNA

Antibiotic that inhibits trans-translation blocks binding of EF-Tu to tmRNA but not to tRNA

ABSTRACT trans-Translation is conserved throughout bacteria and is essential in many species. High-throughput screening identified a tetrazole-based trans-translation inhibitor, KKL-55, that has broad-spectrum antibiotic activity. A biotinylated version of KKL-55 pulled down elongation factor thermo...

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Bibliographic Details
Main Authors: Neeraja Marathe, Ha An Nguyen, John N. Alumasa, Alexandra B. Kuzmishin Nagy, Michael Vazquez, Christine M. Dunham, Kenneth C. Keiler
Format: Article
Language:English
Published: American Society for Microbiology 2023-10-01
Series:mBio
Subjects:
antibiotic
EF-Tu
elfamycin
KKL-55
trans-translation
tRNA
Online Access:https://journals.asm.org/doi/10.1128/mbio.01461-23

Internet

https://journals.asm.org/doi/10.1128/mbio.01461-23

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