AXL confers cell migration and invasion by hijacking a PEAK1-regulated focal adhesion protein network

AXL confers cell migration and invasion by hijacking a PEAK1-regulated focal adhesion protein network

AXL receptor tyrosine kinase has a role in metastasis but the mechanism is unclear. In this study, the authors show that AXL activation can control focal adhesion dynamics via PEAK1 and that AXL-mediated PEAK1 phosphorylation is required for metastasis of triple negative breast cancer cells in vivo.

Bibliographic Details
Main Authors: Afnan Abu-Thuraia, Marie-Anne Goyette, Jonathan Boulais, Carine Delliaux, Chloé Apcher, Céline Schott, Rony Chidiac, Halil Bagci, Marie-Pier Thibault, Dominique Davidson, Mathieu Ferron, André Veillette, Roger J. Daly, Anne-Claude Gingras, Jean-Philippe Gratton, Jean-François Côté
Format: Article
Language:English
Published: Nature Portfolio 2020-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-17415-x

Internet

https://doi.org/10.1038/s41467-020-17415-x

Similar Items