Peptide vaccine-conjugated mesoporous carriers synergize with immunogenic cell death and PD-L1 blockade for amplified immunotherapy of metastatic spinal

Peptide vaccine-conjugated mesoporous carriers synergize with immunogenic cell death and PD-L1 blockade for amplified immunotherapy of metastatic spinal

Abstract The clinical treatment of metastatic spinal tumor remains a huge challenge owing to the intrinsic limitations of the existing methods. Programmed cell death protein 1 (PD1)/programmed cell death ligand 1 (PD-L1) pathway blockade has been explored as a promising immunotherapeutic strategy; h...

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Bibliographic Details
Main Authors: Zhenqing Wang, Liang Chen, Yiqun Ma, Xilei Li, Annan Hu, Huiren Wang, Wenxing Wang, Xiaomin Li, Bo Tian, Jian Dong
Format: Article
Language:English
Published: BMC 2021-08-01
Series:Journal of Nanobiotechnology
Subjects:
Spine metastasis
Peptide vaccine
Immunogenic cell death
Photodynamic therapy
Programmed cell death protein 1/programmed cell death ligand 1 (PD-1/PD-L1) blockades
Online Access:https://doi.org/10.1186/s12951-021-00975-5

Internet

https://doi.org/10.1186/s12951-021-00975-5

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