Class I histone deacetylases (HDAC) critically contribute to Ewing sarcoma pathogenesis

Class I histone deacetylases (HDAC) critically contribute to Ewing sarcoma pathogenesis

Abstract Background Histone acetylation and deacetylation seem processes involved in the pathogenesis of Ewing sarcoma (EwS). Here histone deacetylases (HDAC) class I were investigated. Methods Their role was determined using different inhibitors including TSA, Romidepsin, Entinostat and PCI-34051 a...

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Bibliographic Details
Main Authors: Oxana Schmidt, Nadja Nehls, Carolin Prexler, Kristina von Heyking, Tanja Groll, Katharina Pardon, Heathcliff D. Garcia, Tim Hensel, Dennis Gürgen, Anton G. Henssen, Angelika Eggert, Katja Steiger, Stefan Burdach, Günther H. S. Richter
Format: Article
Language:English
Published: BMC 2021-10-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Ewing sarcoma
Class I HDACs
Expression profiles
Pathogenesis
Targeted therapy
Online Access:https://doi.org/10.1186/s13046-021-02125-z

Internet

https://doi.org/10.1186/s13046-021-02125-z

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