Structures of the R-type human Cav2.3 channel reveal conformational crosstalk of the intracellular segments

Structures of the R-type human Cav2.3 channel reveal conformational crosstalk of the intracellular segments

Voltage-gated Ca2+ channel subtype Cav2.3 represents a potential drug target for neurological diseases. Here, authors report cryo-EM structures of Cav2.3 and its mutant to reveal the crosstalk of intracellular segments, which may facilitate future drug discovery.

Bibliographic Details
Main Authors: Xia Yao, Yan Wang, Zhifei Wang, Xiao Fan, Di Wu, Jian Huang, Alexander Mueller, Sarah Gao, Miaohui Hu, Carol V. Robinson, Yong Yu, Shuai Gao, Nieng Yan
Format: Article
Language:English
Published: Nature Portfolio 2022-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-35026-6

Internet

https://doi.org/10.1038/s41467-022-35026-6

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