Structures of the R-type human Cav2.3 channel reveal conformational crosstalk of the intracellular segments
Voltage-gated Ca2+ channel subtype Cav2.3 represents a potential drug target for neurological diseases. Here, authors report cryo-EM structures of Cav2.3 and its mutant to reveal the crosstalk of intracellular segments, which may facilitate future drug discovery.
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-11-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-35026-6 |
| _version_ | 1811190297038684160 |
|---|---|
| author | Xia Yao Yan Wang Zhifei Wang Xiao Fan Di Wu Jian Huang Alexander Mueller Sarah Gao Miaohui Hu Carol V. Robinson Yong Yu Shuai Gao Nieng Yan |
| author_facet | Xia Yao Yan Wang Zhifei Wang Xiao Fan Di Wu Jian Huang Alexander Mueller Sarah Gao Miaohui Hu Carol V. Robinson Yong Yu Shuai Gao Nieng Yan |
| author_sort | Xia Yao |
| collection | DOAJ |
| description | Voltage-gated Ca2+ channel subtype Cav2.3 represents a potential drug target for neurological diseases. Here, authors report cryo-EM structures of Cav2.3 and its mutant to reveal the crosstalk of intracellular segments, which may facilitate future drug discovery. |
| first_indexed | 2024-04-11T14:49:00Z |
| format | Article |
| id | doaj.art-37a5efd01d2a408e8be2e5778735122b |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-11T14:49:00Z |
| publishDate | 2022-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-37a5efd01d2a408e8be2e5778735122b2022-12-22T04:17:33ZengNature PortfolioNature Communications2041-17232022-11-0113111110.1038/s41467-022-35026-6Structures of the R-type human Cav2.3 channel reveal conformational crosstalk of the intracellular segmentsXia Yao0Yan Wang1Zhifei Wang2Xiao Fan3Di Wu4Jian Huang5Alexander Mueller6Sarah Gao7Miaohui Hu8Carol V. Robinson9Yong Yu10Shuai Gao11Nieng Yan12Department of Molecular Biology, Princeton UniversityDepartment of Biological Sciences, St. John’s UniversityDepartment of Biological Sciences, St. John’s UniversityDepartment of Molecular Biology, Princeton UniversityPhysical and Theoretical Chemistry Laboratory, University of OxfordDepartment of Molecular Biology, Princeton UniversityDepartment of Molecular Biology, Princeton UniversityDepartment of Molecular Biology, Princeton UniversityDepartment of Molecular Biology, Princeton UniversityPhysical and Theoretical Chemistry Laboratory, University of OxfordDepartment of Biological Sciences, St. John’s UniversityDepartment of Molecular Biology, Princeton UniversityDepartment of Molecular Biology, Princeton UniversityVoltage-gated Ca2+ channel subtype Cav2.3 represents a potential drug target for neurological diseases. Here, authors report cryo-EM structures of Cav2.3 and its mutant to reveal the crosstalk of intracellular segments, which may facilitate future drug discovery.https://doi.org/10.1038/s41467-022-35026-6 |
| spellingShingle | Xia Yao Yan Wang Zhifei Wang Xiao Fan Di Wu Jian Huang Alexander Mueller Sarah Gao Miaohui Hu Carol V. Robinson Yong Yu Shuai Gao Nieng Yan Structures of the R-type human Cav2.3 channel reveal conformational crosstalk of the intracellular segments Nature Communications |
| title | Structures of the R-type human Cav2.3 channel reveal conformational crosstalk of the intracellular segments |
| title_full | Structures of the R-type human Cav2.3 channel reveal conformational crosstalk of the intracellular segments |
| title_fullStr | Structures of the R-type human Cav2.3 channel reveal conformational crosstalk of the intracellular segments |
| title_full_unstemmed | Structures of the R-type human Cav2.3 channel reveal conformational crosstalk of the intracellular segments |
| title_short | Structures of the R-type human Cav2.3 channel reveal conformational crosstalk of the intracellular segments |
| title_sort | structures of the r type human cav2 3 channel reveal conformational crosstalk of the intracellular segments |
| url | https://doi.org/10.1038/s41467-022-35026-6 |
| work_keys_str_mv | AT xiayao structuresofthertypehumancav23channelrevealconformationalcrosstalkoftheintracellularsegments AT yanwang structuresofthertypehumancav23channelrevealconformationalcrosstalkoftheintracellularsegments AT zhifeiwang structuresofthertypehumancav23channelrevealconformationalcrosstalkoftheintracellularsegments AT xiaofan structuresofthertypehumancav23channelrevealconformationalcrosstalkoftheintracellularsegments AT diwu structuresofthertypehumancav23channelrevealconformationalcrosstalkoftheintracellularsegments AT jianhuang structuresofthertypehumancav23channelrevealconformationalcrosstalkoftheintracellularsegments AT alexandermueller structuresofthertypehumancav23channelrevealconformationalcrosstalkoftheintracellularsegments AT sarahgao structuresofthertypehumancav23channelrevealconformationalcrosstalkoftheintracellularsegments AT miaohuihu structuresofthertypehumancav23channelrevealconformationalcrosstalkoftheintracellularsegments AT carolvrobinson structuresofthertypehumancav23channelrevealconformationalcrosstalkoftheintracellularsegments AT yongyu structuresofthertypehumancav23channelrevealconformationalcrosstalkoftheintracellularsegments AT shuaigao structuresofthertypehumancav23channelrevealconformationalcrosstalkoftheintracellularsegments AT niengyan structuresofthertypehumancav23channelrevealconformationalcrosstalkoftheintracellularsegments |