Berberine attenuates 5-fluorouracil-induced intestinal mucosal injury by modulating the gut microbiota without compromising its anti-tumor efficacy

Berberine attenuates 5-fluorouracil-induced intestinal mucosal injury by modulating the gut microbiota without compromising its anti-tumor efficacy

Background: 5-Fluorouracil (5-Fu), a prominent chemotherapeutic agent for colorectal cancer (CRC) treatment, is often associated with gastrointestinal toxicities, particularly diarrhea. Our previous study demonstrated that berberine (BBR) ameliorates 5-Fu-induced intestinal mucosal injury by modulat...

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Bibliographic Details
Main Authors: Changhong Wu, Jie Yang, Chenxiao Ye, Hui Wu, Wenxi Shu, Rongrong Li, Sihan Wang, Yi Lu, Haitao Chen, Zewei Zhang, Qinghua Yao
Format: Article
Language:English
Published: Elsevier 2024-07-01
Series:Heliyon
Subjects:
5-Fluorouracil
Berberine
Intestinal mucositis
PI3K/AKT/mTOR pathway
Intestinal flora
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844024105592

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http://www.sciencedirect.com/science/article/pii/S2405844024105592

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