The Bactericidal Fatty Acid Mimetic 2CCA-1 Selectively Targets Pneumococcal Extracellular Polyunsaturated Fatty Acid Metabolism

The Bactericidal Fatty Acid Mimetic 2CCA-1 Selectively Targets Pneumococcal Extracellular Polyunsaturated Fatty Acid Metabolism

ABSTRACT Streptococcus pneumoniae, a major cause of pneumonia, sepsis, and meningitis worldwide, has the nasopharynges of small children as its main ecological niche. Depletion of pneumococci from this niche would reduce the disease burden and could be achieved using small molecules with narrow-spec...

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Bibliographic Details
Main Authors: Elisabeth Reithuber, Priyanka Nannapaneni, Olena Rzhepishevska, Anders E. G. Lindgren, Oleksandr Ilchenko, Staffan Normark, Fredrik Almqvist, Birgitta Henriques-Normark, Peter Mellroth
Format: Article
Language:English
Published: American Society for Microbiology 2020-12-01
Series:mBio
Subjects:
Streptococcus pneumoniae
pneumococci
LytA
small antimicrobial compound
extracellular fatty acid metabolism
FabT
Online Access:https://journals.asm.org/doi/10.1128/mBio.03027-20

Internet

https://journals.asm.org/doi/10.1128/mBio.03027-20

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