Total Synthesis of Pulmonarin B and Design of Brominated Phenylacetic Acid/Tacrine Hybrids: Marine Pharmacophore Inspired Discovery of New ChE and Aβ Aggregation Inhibitors

Total Synthesis of Pulmonarin B and Design of Brominated Phenylacetic Acid/Tacrine Hybrids: Marine Pharmacophore Inspired Discovery of New ChE and Aβ Aggregation Inhibitors

A marine natural product, pulmonarin B (1), and a series of related tacrine hybrid analogues were synthesized and evaluated as cholinesterase (ChE) inhibitors. The in vitro ChE assay results revealed that 1 showed moderate dual acetylcholinesterase (AChE)/ butyrylcholinesterase (BChE) inhibitory act...

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Bibliographic Details
Main Authors: Zhi-Qiang Cheng, Jia-Li Song, Kongkai Zhu, Juan Zhang, Cheng-Shi Jiang, Hua Zhang
Format: Article
Language:English
Published: MDPI AG 2018-08-01
Series:Marine Drugs
Subjects:
pulmonarin B
brominated-phenylacetic acid/tacrine hybrids
acetylcholinesterase
butylcholinesterase
anti-amyloid aggregation
Alzheimer’s disease
Online Access:http://www.mdpi.com/1660-3397/16/9/293

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http://www.mdpi.com/1660-3397/16/9/293

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