OGR1 (GPR68) and TDAG8 (GPR65) Have Antagonistic Effects in Models of Colonic Inflammation

OGR1 (GPR68) and TDAG8 (GPR65) Have Antagonistic Effects in Models of Colonic Inflammation

G-protein-coupled receptors (GPRs), including pro-inflammatory ovarian cancer GPR1 (OGR1/GPR68) and anti-inflammatory T cell death-associated gene 8 (TDAG8/GPR65), are involved in pH sensing and linked to inflammatory bowel disease (IBD). OGR1 and TDAG8 show opposite effects. To determine which effe...

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Bibliographic Details
Main Authors: Leonie Perren, Moana Busch, Cordelia Schuler, Pedro A. Ruiz, Federica Foti, Nathalie Weibel, Cheryl de Vallière, Yasser Morsy, Klaus Seuwen, Martin Hausmann, Gerhard Rogler
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:International Journal of Molecular Sciences
Subjects:
Crohn’s disease
inflammatory bowel disease
OGR1/GPR68
pH-sensing G-protein-coupled receptors
TDAG8/GPR65
ulcerative colitis
Online Access:https://www.mdpi.com/1422-0067/24/19/14855

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https://www.mdpi.com/1422-0067/24/19/14855

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