Shikonin derivatives cause apoptosis and cell cycle arrest in human chondrosarcoma cells via death receptors and MAPK regulation

Shikonin derivatives cause apoptosis and cell cycle arrest in human chondrosarcoma cells via death receptors and MAPK regulation

Abstract Background Although chondrosarcoma is the second most common primary malignant bone tumor, treatment options are limited due to its extensive resistance to a chemo- and radiation therapy. Since shikonin has shown potent anticancer activity in various types of cancer cells, it represents a p...

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Bibliographic Details
Main Authors: Birgit Lohberger, Dietmar Glänzer, Heike Kaltenegger, Nicole Eck, Andreas Leithner, Rudolf Bauer, Nadine Kretschmer, Bibiane Steinecker-Frohnwieser
Format: Article
Language:English
Published: BMC 2022-07-01
Series:BMC Cancer
Subjects:
Chondrosarcoma
Shikonin
Acetylshikonin
Cyclopropylshikonin
Apoptosis
Death receptors
Online Access:https://doi.org/10.1186/s12885-022-09857-x

Internet

https://doi.org/10.1186/s12885-022-09857-x

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