Response and resistance to BRAFV600E inhibition in gliomas: Roadblocks ahead?

Response and resistance to BRAFV600E inhibition in gliomas: Roadblocks ahead?

BRAFV600E represents the most common BRAF mutation in all human cancers. Among central nervous system (CNS) tumors, BRAFV600E is mostly found in pediatric low-grade gliomas (pLGG, ~20%) and, less frequently, in pediatric high-grade gliomas (pHGG, 5-15%) and adult glioblastomas (GBM, ~5%). The integr...

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Bibliographic Details
Main Authors: Monica Capogiri, Andrea J. De Micheli, Alvaro Lassaletta, Denise P. Muñoz, Jean-Philippe Coppé, Sabine Mueller, Ana S. Guerreiro Stucklin
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Oncology
Subjects:
glioma
BRAF inhibitors
drug resistance
BRAFV600E mutation
high-grade glioma (HGG)
low-grade glioma (LGG)
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.1074726/full

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https://www.frontiersin.org/articles/10.3389/fonc.2022.1074726/full

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