Blood donor biobank and HLA imputation as a resource for HLA homozygous cells for therapeutic and research use

Blood donor biobank and HLA imputation as a resource for HLA homozygous cells for therapeutic and research use

Abstract Background Allogeneic therapeutic cells may be rejected if they express HLA alleles not found in the recipient. As finding cell donors with a full HLA match to a recipient requires vast donor pools, the use of HLA homozygous cells has been suggested as an alternative. HLA homozygous cells s...

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Bibliographic Details
Main Authors: Jonna Clancy, Kati Hyvärinen, Jarmo Ritari, Tiina Wahlfors, Jukka Partanen, Satu Koskela
Format: Article
Language:English
Published: BMC 2022-10-01
Series:Stem Cell Research & Therapy
Subjects:
Imputation
Major histocompatibility complex
HLA
Homozygosity
Cell therapy
Thrombocyte
Online Access:https://doi.org/10.1186/s13287-022-03182-7

Internet

https://doi.org/10.1186/s13287-022-03182-7

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